Design, synthesis and biological evaluation of 1,2,3-triazole benzothiazole derivatives as tubulin polymerization inhibitors with potent anti-esophageal cancer activities
Bowen Wu, Wenjing Huang, Yunhe Liu, Qiu-Ge Liu, Jian Song, Tao Hu, Ping Chen, Sai‐Yang Zhang
Topics & Concepts
BenzothiazoleChemistryTubulinMicrotubuleApoptosisCell cycleCell cycle checkpointMicrotubule polymerizationIC50CellBiochemistryIn vitroStereochemistryCell biologyBiologyHippo pathway signaling and YAP/TAZProtein Degradation and InhibitorsUbiquitin and proteasome pathways