Polydatin: a potential NAFLD therapeutic drug that regulates mitochondrial autophagy through SIRT3-FOXO3-BNIP3 and PINK1-PRKN mechanisms - a network pharmacology and experimental investigation
Jing He, Yi-cai Qian, Ying‐Chuan Yin, Jing-rui Kang, T Pan
Topics & Concepts
PINK1SIRT3AutophagyParkinMFN2Sequestosome 1BiologyMitochondrial biogenesisMitophagyMitochondrionSirtuinCancer researchFatty liverFOXO3Cell biologyPharmacologyMitochondrial DNAmitochondrial fusionMedicineSignal transductionDiseaseApoptosisProtein kinase BAcetylationInternal medicineGeneticsParkinson's diseaseGeneLiver Disease Diagnosis and TreatmentMitochondrial Function and PathologySirtuins and Resveratrol in Medicine