A synergistic effect of hydrophobic deep eutectic solvents based on terpenoids and carboxylic acids for tetracycline microextraction
Ksenia Cherkashina, Aleksei Pochivalov, Viktoriia M. Simonova, Firuza M. Shakirova, Andrey Shishov, Andrey Bulatov
Abstract
Hydrophobic deep eutectic solvents were investigated for tetracycline microextraction. It was found that a deep eutectic solvent consisting of thymol and octanoic acid provided a synergistic effect on tetracycline extraction. In this paper, a novel liquid-liquid microextraction procedure for the HPLC-DAD determination of tetracyclines in milk samples was proposed.
Topics & Concepts
TerpenoidEutectic systemChemistryTetracyclineChromatographyHigh-performance liquid chromatographyOrganic chemistryStereochemistryBiochemistryAntibioticsAlloyAnalytical chemistry methods developmentIonic liquids properties and applicationsPharmaceutical and Antibiotic Environmental Impacts