Melatonin suppresses inflammation and blood‒brain barrier disruption in rats with vascular dementia possibly by activating the SIRT1/PGC-1α/PPARγ signaling pathway
Phakkawat Thangwong, Pranglada Jearjaroen, Chainarong Tocharus, Piyarat Govitrapong, Jiraporn Tocharus
Topics & Concepts
MelatoninInflammationInternal medicineEndocrinologyBlood–brain barrierSirtuin 1ReceptorMorris water navigation taskMelatonin receptorPeroxisome proliferator-activated receptorMedicineChemistryPharmacologyHippocampusCentral nervous systemBiochemistryDownregulation and upregulationGeneNeurological Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration MechanismsBiochemical effects in animals