Maternal blood metal concentrations and whole blood DNA methylation during pregnancy in the Early Autism Risk Longitudinal Investigation (EARLI)
Max T. Aung, Kelly M. Bakulski, Jason I. Feinberg, John Dou, John D. Meeker, Bhramar Mukherjee, Rita Loch‐Caruso, Christine Ladd‐Acosta, Heather E. Volk, Lisa Croen, Irva Hertz‐Picciotto, Craig J. Newschaffer, M. Daniele Fallin
Abstract
< 0.05) with cadmium, lead, and manganese were highly correlated (Pearson ρ > 0.86). DNA methylation sites associated with lead and manganese may be potential biomarkers of exposure or implicate downstream gene pathways.
Topics & Concepts
DNA methylationMethylationBiologyWhole bloodCpG siteInternal medicineGeneGeneticsImmunologyGene expressionMedicineEpigenetics and DNA MethylationHeavy Metal Exposure and ToxicityChild Nutrition and Water Access