Study on the antithrombotic effect and physiological mechanism of okanin
Yi Liu, Binbing Xiong, Xinyu Qiu, Haiyan Hao, Ailong Sha
Abstract
in animal plasma. It is concluded that okanin can significantly inhibit thrombosis, and its physiological mechanisms were related to affecting the activation of related coagulation factors in endogenous and exogenous coagulation pathways, affecting the physiological characteristics of platelets, repairing damaged vascular endothelial cells and enhancing the activity of the fibrinolytic system.
Topics & Concepts
Partial thromboplastin timeAntithromboticThromboxane B2ChemistryPharmacologyPlasminogen activatorThrombin timePlateletIn vivoVon Willebrand factorProthrombin timeBleeding timeAntithrombinPlatelet-poor plasmaInternal medicineMedicineThrombinBiochemistryHeparinBiologyPlatelet aggregationBiotechnologyInflammatory mediators and NSAID effectsOxidative Organic Chemistry ReactionsVanadium and Halogenation Chemistry