Affinity-matured DLL4 ligands as broad-spectrum modulators of Notch signaling
David González-Pérez, Satyajit Das, Daniel Antfolk, Hadia S. Ahsan, Elliot Medina, Carolyn E. Dundes, Rayyan T. Jokhai, Emily D. Egan, Stephen C. Blacklow, Kyle M. Loh, Paulo C. Rodrı́guez, Vincent C. Luca
Abstract
Engineering of a high-affinity Delta-like variant, named DeltaMAX, potently activates Notch signaling when provided in a bead-bound or cellular format, while administration as a soluble decoy inhibits signaling.
Topics & Concepts
Notch signaling pathwayCell biologyReceptorSignal transductionEffectorHes3 signaling axisLigand (biochemistry)Cell signalingBroad spectrumDecoyChemistryBiologyBiochemistryCombinatorial chemistryDevelopmental Biology and Gene RegulationNeuroinflammation and Neurodegeneration MechanismsRetinal Development and Disorders