Roles of WNK4 and SPAK in K<sup>+</sup>-mediated dephosphorylation of the NaCl cotransporter
Anindit Mukherjee, Chao-Ling Yang, James A. McCormick, Kevin J. Martz, Avika Sharma, David H. Ellison
Abstract
Although a great deal is known about mechanisms by which thiazide-sensitive NaCl cotransporter is phosphorylated and activated, much less is known about dephosphorylation. Here, we show that rapid dephosphorylation by high K + depends on the Cl − sensitivity of with-no-lysine 4 and the rapid dephosphorylation of STE20/SPS1-related proline-alanine-rich protein kinase, primarily along the early distal convoluted tubule.
Topics & Concepts
DephosphorylationPhosphorylationKinasePhosphataseExtracellularDistal convoluted tubuleCotransporterCell biologyChemistryBiochemistryBiologyReabsorptionEndocrinologyKidneySodiumOrganic chemistryIon Transport and Channel RegulationMagnesium in Health and DiseaseRenal function and acid-base balance