A model of the aged lung epithelium in idiopathic pulmonary fibrosis
Hoora Shaghaghi, Karina Cuevas-Mora, Rachel Para, Cara Tran, Willy Roque, Matthew J. Robertson, Iván O. Rosas, Ross Summer, Freddy Romero
Abstract
model that closely resembles the aberrant lung epithelium in IPF. We propose that this simple yet powerful tool could help uncover new biological mechanisms and assist in developing new pharmacological tools to treat the disease.
Topics & Concepts
Idiopathic pulmonary fibrosisProteostasisAlveolar EpitheliumEpitheliumLungBiologyPirfenidoneCell biologyPulmonary fibrosisImmunologyDiseasePathologyMedicineInternal medicineGeneticsInterstitial Lung Diseases and Idiopathic Pulmonary FibrosisPulmonary Hypertension Research and TreatmentsChronic Obstructive Pulmonary Disease (COPD) Research