<italic>Salmonella typhimurium</italic> may support cancer treatment: a review
Zeyu Yang, Ling Zou, Bing Yue, Minwei Hu
Abstract
<p indent="0mm">Antitumour treatments are evolving, including bacteria-mediated cancer therapy which is concurrently an ancient and cutting-edge approach. <italic>Salmonella typhimurium</italic> is a widely studied bacterial species that colonizes tumor tissues, showing oncolytic and immune system-regulating properties. It can be used as a delivery vector for genes and drugs, supporting conventional treatments that lack tumor-targeting abilities. This article summarizes recent evidence on the anticancer mechanisms of <italic>S</italic>. <italic>typhimurium</italic> alone and in combination with other anticancer treatments, suggesting that it may be a suitable approach to disease management.
Topics & Concepts
SalmonellaOncolytic virusImmune systemBacteriaCancer researchCancerMicrobiologyBiologyMedicineTumor cellsImmunologyInternal medicineGeneticsCancer Research and TreatmentsNanoplatforms for cancer theranosticsVirus-based gene therapy research