Double crosslinking decellularized bovine pericardium of dialdehyde chondroitin sulfate and zwitterionic copolymer for bioprosthetic heart valves with enhanced antithrombogenic, anti-inflammatory and anti-calcification properties
Shubin Shi, Mengyue Hu, Peng Xu, Can Cheng, Shaoxiong Feng, Xinyun Pu, Xixun Yu
Abstract
results revealed that P(APM/MPC)-OCS-BP exhibited an excellent anti-calcification property. In a word, this simple cooperative crosslinking strategy provides a novel solution to obtain BHVs with good mechanical properties, and HUVEC-cytocompatibility, anti-coagulation, anti-inflammatory and anti-calcification properties. It might be a promising alternative to GA-fixed BP and exhibited good prospects in clinical applications.
Topics & Concepts
CalcificationDecellularizationCopolymerMaterials scienceChondroitin sulfatePolymer chemistryBiomedical engineeringGlycosaminoglycanScaffoldPolymerMedicineComposite materialAnatomyPathologyCardiac Valve Diseases and TreatmentsElectrospun Nanofibers in Biomedical ApplicationsCardiac and Coronary Surgery Techniques