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miR-421 up-regulation by the oleanolic acid derivative K73-03 regulates epigenetically SPINK1 transcription in pancreatic cancer cells leading to metabolic changes and enhanced apoptosis

Abdullah Shopit, Xiaodong Li, Zhongyuan Tang, Zhongyuan Tang, Mohammed Awsh, Loubna Shobet, Mengyue Niu, Hongyan Wang, Haithm Mousa, Mohammed Alshwmi, Tsehaye Tesfaldet, Yaser Gamallat, Hailong Li, Peng Chu, Nisar Ahmad, Yazeed Jamalat, Jie Ai, Eskandar Qaed, Marwan Almoiliqy, Shisheng Wang, Zeyao Tang, Zeyao Tang

2020Pharmacological Research30 citationsDOI

Topics & Concepts

Pancreatic cancerAutophagyApoptosisCancer researchBiologymicroRNAEpigeneticsCancer cellGemcitabineCancerCell biologyChemistryBiochemistryGeneticsGeneProtein Tyrosine PhosphatasesATP Synthase and ATPases ResearchNF-κB Signaling Pathways
miR-421 up-regulation by the oleanolic acid derivative K73-03 regulates epigenetically SPINK1 transcription in pancreatic cancer cells leading to metabolic changes and enhanced apoptosis | Litcius