Wound healing in aged skin exhibits systems-level alterations in cellular composition and cell-cell communication
Remy Vu, Suoqin Jin, Peng Sun, Daniel Haensel, Quy Nguyen, Morgan Dragan, Kai Kessenbrock, Qing Nie, Xing Dai
Abstract
macrophage subset that is more likely to signal to fibroblasts via interleukin (IL)-1 than in young counterparts. We predict systems-level differences in the number, strength, route, and signaling mediators of putative cell-cell communications in young and aged skin wounds. Our study exposes numerous cellular/molecular targets for functional interrogation and provides a hypothesis-generating resource for future wound healing studies.
Topics & Concepts
Wound healingFibroblastCellCell typeInflammationBiologyCell biologyImmune systemImmunologyCell migrationCell signalingSignal transductionCell cultureGeneticsWound Healing and TreatmentsSkin Protection and AgingPressure Ulcer Prevention and Management