Aluminum-Decorated MIL-100(Fe) Nanozyme for the Detection of Glutathione
Lin Cui, Xinshuo Zhao, Jiankang Zhang, Zhan Zhou, Dong Lin, Yong Qin
Abstract
Nanozymes are nanomaterials with natural enzyme characteristics, which are expected to be potential substitutes of traditional enzymes. In this study, the 1Al/MIL-100(Fe) nanozymes with excellent peroxidase-like activity were synthesized by the ultrathin modification (one-cycle Al 2 O 3 ) strategy of atomic layer deposition, whose peroxidase-like activity is almost doubled compared with MIL-100(Fe) nanozymes. Investigation of the catalytic mechanism indicates that the increased amount of hydroxyl radical is responsible for the much-enhanced peroxidase-like activity of 1Al/MIL-100(Fe) nanozymes. Furthermore, the catalytic effect of the designed nanozymes is inhibited by glutathione through consuming the oxidized 3,3′,5,5′-tetramethylbenzidine in the reaction system. The 1Al/MIL-100(Fe) nanozymes also achieve the sensitive and selective detection of glutathione, which have an excellent linear response to glutathione concentration in the range 0.01–1000 μM with a detection limit of 2.2 nM. The ultrathin modification strategy can be potentially extended to synthesize other high-efficiency nanozyme materials.