A non-toxic poly(resorcinol) modified glassy carbon electrode for highly selective square wave voltammetry determination of aspirin in tablet formulations and human urine samples
Adane Kassa, Zelalem Bitew, Atakilt Abebe
Abstract
In this study, a sensitive square wave voltammetric method using poly(resorcinol) modified glassy carbon electrode (poly(reso)/GCE) was prepared for the determination of aspirin (ASA) in pharmaceutical tablet and biological fluid samples. CV and EIS were verify the modification of the GCE by a biosensor polymer that raised the electrocatalytic activity of poly(reso)/GCE towards an oxidation of ASA. Appearance of a single irreversible oxidative peak for ASA with fivefold current enhancement and much reduced potential at poly(reso)/GCE compared to bare GCE demonstrated catalytic property of the modifier. The peak current response with optimized experimental conditions at the poly(reso)/GCE exhibited a linear dependence with ASA concentration within the range 0.05–400.0 μM, with LoD 2.0 nM. The levels of ASA in four tablet brands ranged from 94.65 to 100.00% of their assigned values revealed the effectiveness of the developed method. The spike recovery results in pharmaceutical samples were ranged from 99.60 to 101.43% and urine samples 98.95% to 102.7%. Wider dynamic range, lower LoD, excellent spike recovery, and interference recovery results with errors <4.82% and good stability of the modifier, validated the potential applicability of the method based on poly(reso)/GCE for determination of ASA in real samples.