Visible‐Light‐Induced Radical Defluoroborylation of Trifluoromethyl Alkenes: An Access to <i>gem</i>‐Difluoroallylboranes
Guojun Chen, Liling Wang, Xiaozu Liu, Peijun Liu
Abstract
Abstract A photoredox‐catalyzed defluoroborylation of trifluoromethyl alkenes with N ‐heterocyclic carbene boranes is described for the synthesis of gem ‐difluoroallylboranes. This protocol exhibits a broad substrate scope and good functional group compatibility, which enables the late‐stage functionalization of structurally complex compounds. Further transformations of the defluoroborylation products to valuable CF 2 ‐containing molecules are also demonstrated. magnified image
Topics & Concepts
ChemistryTrifluoromethylBoranesTrifluoromethylationCarbeneSurface modificationMoleculePhotoredox catalysisRadicalVisible spectrumCombinatorial chemistryPhotochemistryCatalysisOrganic chemistryBoronPhotocatalysisAlkylOptoelectronicsPhysicsPhysical chemistryFluorine in Organic ChemistryRadical Photochemical ReactionsInorganic Fluorides and Related Compounds