Drug screening in zebrafish larvae reveals inflammation-related modulators of secondary damage after spinal cord injury in mice
Ana‐Maria Oprişoreanu, Fari Ryan, Claire Richmond, Yuliya Dzekhtsiarova, Neil O. Carragher, Thomas Becker, Samuel David, Catherina G. Becker
Abstract
Our screen revealed H2 receptor signaling as a promising target for future therapeutic interventions in spinal cord injury. This work highlights the usefulness of the zebrafish model for rapid screening of drug libraries to identify therapeutics to treat mammalian spinal cord injury.
Topics & Concepts
ZebrafishInflammationSpinal cordSpinal cord injuryPharmacologyCimetidineMedicineReceptorBiologyImmunologyNeuroscienceInternal medicineGeneBiochemistryZebrafish Biomedical Research ApplicationsSpinal Cord Injury ResearchNeuroscience of respiration and sleep