An injectable gellan gum-based hydrogel that inhibits <i>Staphylococcus aureus</i> for infected bone defect repair
Laijun Xu, Qing Ye, Jing Xie, Jiaojiao Yang, Wentao Jiang, He Yuan, Jiyao Li
Abstract
. We successfully established an infected calvarial defect rat model. Bacterial colony numbers were significantly lower in tissues surrounding the bone in rats of the GG/nHA/CHX group after debride surgery and hydrogel implantation in the defect regions than in rats of the blank group. Rats in the GG/nHA/CHX group exhibited significantly increased new bone formation compared to those in the blank group at 4 and 8 weeks. These findings indicate that gellan gum-based hydrogel with nHA/CHX can accelerate the repair of infected bone defects.
Topics & Concepts
Gellan gumStaphylococcus aureusChlorhexidineDentistryMaterials scienceMicrobiologyMedicineBacteriaBiologyGeneticsBone Tissue Engineering MaterialsPeriodontal Regeneration and TreatmentsDental Implant Techniques and Outcomes