Cutaneous Rosai-Dorfman Disease: A Treatment Challenge
Anna Gawdzik, Bogna Ziarkiewicz‐Wróblewska, Iwona Chlebicka, Alina Jankowska‐Konsur, Jacek C. Szepietowski, Joanna Maj
Abstract
Rosai-Dorfman disease (RDD) is a benign histiocytosis that rarely manifests as a purely cutaneous form. Its differential diagnosis and treatment can pose a challenge to both clinicians and pathomorphologists. We present the case of a 69-year-old woman with cutaneous RDD presenting as multiple nodules on the right thigh who was treated with low-dose methotrexate weekly for > 1 year with a partial response.
Topics & Concepts
Rosai–Dorfman diseaseMedicineHistiocytosisMethotrexateDifferential diagnosisDermatologyDiseasePathologySurgeryHistiocytic Disorders and TreatmentsParvovirus B19 Infection StudiesTumors and Oncological Cases