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Amsacrine downregulates BCL2L1 expression and triggers apoptosis in human chronic myeloid leukemia cells through the SIDT2/NOX4/ERK/HuR pathway

Yuan‐Chin Lee, Jing‐Ting Chiou, Liangjun Wang, Ying‐Jung Chen, Long‐Sen Chang

2023Toxicology and Applied Pharmacology13 citationsDOI

Topics & Concepts

AmsacrineK562 cellsDownregulation and upregulationApoptosisMyeloid leukemiaCell biologyMAPK/ERK pathwayProgrammed cell deathBiologyChemistryCancer researchMolecular biologyCytotoxicityKinaseBiochemistryGeneIn vitroCell death mechanisms and regulationAcute Lymphoblastic Leukemia researchCancer therapeutics and mechanisms
Amsacrine downregulates BCL2L1 expression and triggers apoptosis in human chronic myeloid leukemia cells through the SIDT2/NOX4/ERK/HuR pathway | Litcius