Purinergic P2X7 Receptor Mediates the Elimination of Trichinella spiralis by Activating NF-κB/NLRP3/IL-1β Pathway in Macrophages
Fei Guan, Wangfang Jiang, Yang Bai, Xiao Hou, Chunjie Jiang, Chongyang Zhang, Muziazia Lupemba Jacques, Wenqi Liu, Jiahui Lei
Abstract
Trichinellosis is one of most neglected foodborne zoonoses worldwide. During Trichinella spiralis infection, the intestinal immune response is the first line of defense and plays a vital role in the host’s resistance.
Topics & Concepts
Trichinella spiralisBiologyPurinergic receptorImmune systemImmunologyMicrobiologyTrichinellaReceptorVirologyHelminthsBiochemistryAdenosine and Purinergic SignalingCOVID-19 Impact on ReproductionParasitic infections in humans and animals