Organocatalytic asymmetric α-functionalizations of β-ketoesters with hypervalent iodine-based reagents and catalysts
Christopher Mairhofer, Lotte Stockhammer, Mario Waser
Abstract
The introduction of hypervalent iodine-based electrophilic functional group transfer reagents and the development of catalysis concepts making use of in situ generated hypervalent iodine species has significantly contributed to the advancement of organic synthesis. Especially asymmetric -functionalizations of prochiral pronucleophiles have been very successfully introduced by utilizing hypervalent iodine chemistry recently. Among the different classes of commonly used pronucleophiles, prochiral -ketoesters emerged as compounds of particular interest. Inspired by impressive recent reports, this short review therefore discusses different concepts using hypervalent iodine chemistry in asymmetric organocatalytic -functionalization reactions of prochiral -ketoesters.