A Comparative Study of Health Efficacy Indicators in Subjects with T2DM Applying Power Cycling to 12 Weeks of Low-Volume High-Intensity Interval Training and Moderate-Intensity Continuous Training
Jun Li, Wei Cheng, Haifeng Ma
Abstract
This study is aimed at comparing the effects of different exercise intensities, namely, high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT), on body composition, heart and lung fitness, and blood glucose, and blood pressure indices in patients with type 2 diabetes mellitus (T2DM), using power cycling. A total of 96 T2DM volunteers who met the inclusion criteria were recruited from a hospital in Yangpu, Shanghai. Based on the blood index data of their medical examination results which comprised blood pressure, fasting blood glucose, hemoglobin A1c (HbA1c), and insulin, 37 volunteers were included in the study. Exercise prescription was determined based on T2DM exercise guidelines combined with medical diagnosis and exercise test results, and the patients were randomly assigned to three groups: HIIT group, MICT group, and control (CON) group. HIIT involved one-minute power cycling (80%–95% maximal oxygen uptake (VO2max)), one-minute passive or active rest (25%–30% VO2max), and two-minute rounds of eight groups. MICT required the use of a power bike for 30 minutes of continuous training (50%–70% VO2max) five times a week. The CON group was introduced to relevant medicine, exercise, and nutrition knowledge. The exercise interventions were completed under the supervision of an exercise instructor and hospital doctors. The same indicators were measured after 12 weeks of intervention, and the results of the two tests within and between groups were analyzed for comparison. The weight index of the MICT intervention showed statistically significant within-group differences ( <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M1"> <a:mtext>difference</a:mtext> <a:mo>=</a:mo> <a:mn>3.52</a:mn> </a:math> , 95% <c:math xmlns:c="http://www.w3.org/1998/Math/MathML" id="M2"> <c:mtext>CI</c:mtext> <c:mo>=</c:mo> <c:mn>2.11</c:mn> </c:math> –4.92, <e:math xmlns:e="http://www.w3.org/1998/Math/MathML" id="M3"> <e:mi>p</e:mi> <e:mo>=</e:mo> <e:mn>0.001</e:mn> <e:mo><</e:mo> <e:mn>0.01</e:mn> </e:math> ); group differences for the MICT and CON groups were also statistically significant ( <g:math xmlns:g="http://www.w3.org/1998/Math/MathML" id="M4"> <g:mtext>difference</g:mtext> <g:mo>=</g:mo> <g:mn>3.52</g:mn> <g:mo>±</g:mo> <g:mn>2.09</g:mn> </g:math> , <i:math xmlns:i="http://www.w3.org/1998/Math/MathML" id="M5"> <i:mtext>Cd</i:mtext> <i:mn>1</i:mn> <i:mo>=</i:mo> <i:mo>−</i:mo> <i:mn>0.39</i:mn> <i:mo>±</i:mo> <i:mn>1.25</i:mn> </i:math> , <k:math xmlns:k="http://www.w3.org/1998/Math/MathML" id="M6"> <k:mi>p</k:mi> <k:mo>=</k:mo> <k:mn>0.004</k:mn> <k:mo><</k:mo> <k:mn>0.01</k:mn> </k:math> ). Body mass index (BMI) analysis revealed that the overall means of BMI indicators were not statistically different between groups ( <m:math xmlns:m="http://www.w3.org/1998/Math/MathML" id="M7"> <m:mi>F</m:mi> <m:mo>=</m:mo> <m:mn>0.369</m:mn> </m:math> , <o:math xmlns:o="http://www.w3.org/1998/Math/MathML" id="M8"> <o:mi>p</o:mi> <o:mo>=</o:mo> <o:mn>0.694</o:mn> <o:mo>></o:mo> <o:mn>0.05</o:mn> </o:math> ) and the before and after values of the MICT and CON ( <q:math xmlns:q="http://www.w3.org/1998/Math/MathML" id="M9"> <q:mtext>difference</q:mtext> <q:mo>=</q:mo> <q:mo>−</q:mo> <q:mn>1.30</q:mn> <q:mo>±</q:mo> <q:mn>0.79</q:mn> </q:math> , <s:math xmlns:s="http://www.w3.org/1998/Math/MathML" id="M10"> <s:mtext>Cd</s:mtext> <s:mn>1</s:mn> <s:mo>=</s:mo> <s:mo>−</s:mo> <s:mn>0.18</s:mn> <s:mo>±</s:mo> <s:mn>0.45</s:mn> </s:math> , <u:math xmlns:u="http://www.w3.org/1998/Math/MathML" id="M11"> <u:mi>p</u:mi> <u:mo>=</u:mo> <u:mn>0.001</u:mn> <u:mo><</u:mo> <u:mn>0.01</u:mn> </u:math> ). No statistically significant difference was observed in the overall mean VO2max index between the groups after the 12-week intervention ( <w:math xmlns:w="http://www.w3.org/1998/Math/MathML" id="M12"> <w:mi>F</w:mi> <w:mo>=</w:mo> <w:mn>2.51</w:mn> </w:math> , <y:math xmlns:y="http://www.w3.org/1998/Math/MathML" id="M13"> <y:mi>p</y:mi> <y:mo>=</y:mo> <y:mn>0.100</y:mn> <y:mo>></y:mo> <y:mn>0.05</y:mn> </y:math> ). A statistically significant difference was found in the overall means of the data between the two groups ( <ab:math xmlns:ab="http://www.w3.org/1998/Math/MathML" id="M14"> <ab:mtext>difference</ab:mtext> <ab:mo>=</ab:mo> <ab:mn>0.32</ab:mn> </ab:math> , 95% <cb:math xmlns:cb="http://www.w3.org/1998/Math/MathML" id="M15"> <cb:mtext>CI</cb:mtext> <cb:mo>=</cb:mo> <cb:mn>0.23</cb:mn> </cb:math> –0.40, <eb:math xmlns:eb="http://www.w3.org/1998/Math/MathML" id="M16"> <eb:mi>p</eb:mi> <eb:mo>=</eb:mo> <eb:mn>0.001</eb:mn> <eb:mo><</eb:mo> <eb:mn>0.01</eb:mn> </eb:math> ). Analysis of fasting blood glucose (FBG) indicators revealed statistically significant differences between the MICT and control groups ( <gb:math xmlns:gb="http://www.w3.org/1998/Math/MathML" id="M17"> <gb:mi>p</gb:mi> <gb:mo>=</gb:mo> <gb:mn>0.028</gb:mn> <gb:mo><</gb:mo> <gb:mn>0.05</gb:mn> </gb:math> ). Analysis of HbA1c and fasting insulin (FI) indicators revealed no statistically significant difference in the overall HbA1c index after the 12-week exercise intervention ( <ib:math xmlns:ib="http://www.w3.org/1998/Math/MathML" id="M18"> <ib:mi>F</ib:mi> <ib:mo>=</ib:mo> <ib:mn>0.523</ib:mn> </ib:math> , <kb:math xmlns:kb="http://www.w3.org/1998/Math/MathML" id="M19"> <kb:mi>p</kb:mi> <kb:mo>=</kb:mo> <kb:mn>0.598</kb:mn> <kb:mo>></kb:mo> <kb:mn>0.05</kb:mn> </kb:math> ), and the overall difference before and after the experiment between the groups was statistically significant ( <mb:math xmlns:mb="http://www.w3.org/1998/Math/MathML" id="M20"> <mb:mi>F</mb:mi> <mb:mo>=</mb:mo> <mb:mn>6.13</mb:mn> </mb:math> , <ob:math xmlns:ob="http://www.w3.org