Lipidation of <i>Haemophilus influenzae</i> Antigens P6 and OMP26 Improves Immunogenicity and Protection against Nasopharyngeal Colonization and Ear Infection
Ravinder Kaur, Michael E. Pichichero
Abstract
T-cell memory. Passive transfer of sera from L-OMP26ϕNL-P6-vaccinated mice to recipient infant mice reduced NP colonization and ear bulla NTHi density. We conclude that L-P6, L-OMP26, and fusion constructs generate enhanced antibody responses and protection from NP colonization and middle ear infection by NTHi in mice.
Topics & Concepts
ImmunogenicityHaemophilus influenzaeColonizationBiologyImmunologyAntigenMicrobiologyPneumoniaLipid-anchored proteinPasteurellaceaeVirologyMedicineAntibioticsInternal medicineApoptosisBiochemistryAutophagyBacterial Infections and VaccinesPneumonia and Respiratory InfectionsImmune Response and Inflammation