Hemoglobin-loaded ZIF-8 nanoparticles equipped with PEGylated metal-phenolic network coatings: an oxygen carrier with antioxidant and stealth properties
Clara Coll-Satue, Eva Cabrera San Millán, Michelle Maria Theresia Jansman, Lisa Arnholdt, Leticia Hosta‐Rigau
Abstract
. Furthermore, the NPs showed excellent biocompatibility in terms of cell viability and hemolysis rate studies. They also efficiently bound and released oxygen across multiple cycles, demonstrating preserved functionality. These attributes highlight the potential of our novel HBOC as an effective oxygen delivery system and position our formulation as a promising candidate for clinical application in critical care, providing a strategic alternative to traditional blood transfusions.
Topics & Concepts
Materials scienceNanoparticleHemoglobinReactive oxygen speciesOxygenAntioxidantChemical engineeringNanotechnologyChemistryOrganic chemistryBiochemistryEngineeringNanoplatforms for cancer theranosticsAnalytical Chemistry and SensorsHemoglobin structure and function