Phthalimide–benzoic acid hybrids as potent aldose reductase inhibitors: Synthesis, enzymatic kinetics, and in silico characterization
Dafina Hoti, Arleta Rifati Nixha, Hatice Esra Duran, Mustafa Arslan, Gizem Yıldıztekin, Abdulilah Ece, Cüneyt Türkeş
Topics & Concepts
ChemistryIn silicoAldose reductaseBiochemistryEnzymeAldose reductase inhibitorAldehyde ReductaseDocking (animal)Active siteNon-competitive inhibitionEnzyme inhibitorCytotoxicityBinding siteIn vivoMolecular modelRecombinant DNAReductaseStereochemistryIn vitroRational designStructure–activity relationshipMixed inhibitionMechanism of actionAldose Reductase and TaurineEnzyme function and inhibitionChemical synthesis and pharmacological studies