Doxycycline at subantimicrobial dose combined with escitalopram reverses depressive-like behavior and neuroinflammatory hippocampal alterations in the lipopolysaccharide model of depression
Bruna Stefânia Ferreira Mello, Adriano José Maia Chaves Filho, Charllyany Sabino Custódio, Patrícia de Araújo Rodrigues, Jaqueline Vieira Carletti, Silvânia Maria Mendes Vasconcelos, Francisca Cléa Florenço de Sousa, Lia Lira Olivier Sanders, Danielle S. Macêdo
Topics & Concepts
EscitalopramDoxycyclinePharmacologyBehavioural despair testAntidepressantLipopolysaccharideNeuroprotectionAnhedoniaProinflammatory cytokineMAPK/ERK pathwayCREBMedicineHippocampusInflammationKinaseInternal medicineChemistryBiochemistryAntibioticsDopamineTranscription factorGeneTryptophan and brain disordersStress Responses and CortisolNeuroinflammation and Neurodegeneration Mechanisms