Does SGLT1 inhibition add to the benefits of SGLT2 inhibition in the prevention and treatment of heart failure?
Bertram Pitt, Deepak L. Bhatt, Marco Metra
Abstract
Selectivity of SGLT inhibitors and possible mechanisms of action. FGF21, fibroblast growth factor 21; Ox, oxidative; PGC-1α, peroxisome proliferator-activated receptor gamma coactivator 1-alpha; ROS, reactive oxidative stress; SGLT, sodium glucose cotransporter; SIRT1, sirtuin-1.
Topics & Concepts
MedicineOxidative stressSirtuinCoactivatorFGF21PharmacologySirtuin 1ReceptorEndocrinologyInternal medicineTranscription factorBiochemistryFibroblast growth factorDownregulation and upregulationAcetylationGeneChemistryHeart Failure Treatment and ManagementCardiovascular Function and Risk FactorsCardiac Ischemia and Reperfusion