Evaluation of Synergistic Activity of Isavuconazole or Voriconazole plus Anidulafungin and the Occurrence and Genetic Characterization of Candida auris Detected in a Surveillance Program
Michael A. Pfaller, S. A. Messer, Lalitagauri M. Deshpande, Paul R. Rhomberg, Eric Utt, Mariana Castanheira
Abstract
A total of 15 Candida auris isolates from the SENTRY antimicrobial surveillance program between 2006 and 2019 were combined with 21 isolates from other collections for the evaluation of antifungal susceptibility and synergy against anidulafungin plus voriconazole or isavuconazole using the checkerboard method. Surveillance isolates were analyzed for genetic relatedness and resistance mechanisms.
Topics & Concepts
AnidulafunginVoriconazoleCandida aurisFluconazoleBiologyMicrobiologyEtestMultilocus sequence typingMicafunginCaspofunginGenotypeAntimicrobialAntifungalGeneticsGeneAntifungal resistance and susceptibilityFungal Infections and StudiesInfectious Diseases and Mycology