One-Pot Four-Component Coupling Approach to Polyheterocycles: 6<i>H</i>-Furo[3,2-<i>f</i>]pyrrolo[1,2-<i>d</i>][1,4]diazepine
Seok Hyun Yoon, Sung June Kim, Ikyon Kim
Abstract
][1,4]diazepine, was generated by a one-pot four-component coupling reaction where multiple bonds (three C-C, one C-O, and one C-N) were formed through a domino sequence. Two heterocyclic rings (furan and diazepine) were sequentially constructed from the monocyclic pyrrole derivative under environment-friendly reaction conditions to furnish the tricyclic fused scaffold.
Topics & Concepts
DiazepineChemistryDerivative (finance)PyrroleFuranDominoComponent (thermodynamics)Cascade reactionStereochemistryTricyclicSequence (biology)Coupling reactionCoupling (piping)Combinatorial chemistryRing (chemistry)Medicinal chemistryOrganic chemistryCatalysisThermodynamicsBiochemistryMechanical engineeringEngineeringFinancial economicsEconomicsPhysicsMulticomponent Synthesis of HeterocyclesSynthesis and pharmacology of benzodiazepine derivativesSynthesis and Biological Evaluation