A DNA tetrahedron-loaded natural photosensitizer with aggregation-induced emission characteristics for boosting fluorescence imaging-guided photodynamic therapy
Wei Zhu, Ke Ma, Zhi‐Chao Yan, Qian Wu, Dong Wang, Ben Zhong Tang
Abstract
A natural AIE-active PS (PaH) is utilized to bind into DNA-T for cancer theranostics. The constructed PaH@DNA-T exhibits highly boosted fluorescence intensity and ROS generation, as well as much higher cell uptake efficiency.
Topics & Concepts
PhotosensitizerAggregation-induced emissionFluorescencePhotodynamic therapyBoosting (machine learning)DNAFluorescence-lifetime imaging microscopyTetrahedronMaterials sciencePhotochemistryChemistryBiophysicsOpticsBiochemistryCrystallographyBiologyComputer scienceOrganic chemistryPhysicsMachine learningNanoplatforms for cancer theranosticsAdvanced biosensing and bioanalysis techniquesLuminescence and Fluorescent Materials