A highly conserved 3 <sub>10</sub> helix within the kinesin motor domain is critical for kinesin function and human health
Aileen J. Lam, Lu Rao, Yuzu Anazawa, Kyoko Okada, Kyoko Chiba, Mariah Dacy, Shinsuke Niwa, Arne Gennerich, Dan W. Nowakowski, Richard J. McKenney
Abstract
helix facilitates a specific K-loop conformation that is critical for its function. We find that the function of this proline is conserved in kinesin-1, revealing a fundamental principle of the kinesin motor mechanism.
Topics & Concepts
KinesinFunction (biology)Motor functionMotor proteinDomain (mathematical analysis)BiologyComputational biologyCell biologyGeneticsMicrotubuleMedicineMathematicsMathematical analysisPhysical medicine and rehabilitationMicrotubule and mitosis dynamicsCellular transport and secretionGenetics and Neurodevelopmental Disorders