Epigenomic landscape and 3D genome structure in pediatric high-grade glioma
Juan Wang, Tina Huang, Ye Hou, Elizabeth T. Bartom, Xinyan Lu, Ali Shilatifard, Feng Yue, Amanda Saratsis
Abstract
Together, our results imply three-dimensional genome alterations may play a critical role in the pHGG epigenetic landscape and contribute to tumorigenesis.
Topics & Concepts
EpigenomicsGliomaGenomeComputational biologyBiologyGeneEpigeneticsGene expressionGeneticsDNA methylationProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysGenomics and Chromatin Dynamics