The Long Pentraxin 3 (PTX3) Suppresses Immunity to Cutaneous Leishmaniasis by Regulating CD4+ T Helper Cell Response
Gaurav Gupta, Zhirong Mou, Ping Jia, Rohit Sharma, Romaniya Zayats, Sayonara M. Viana, Lianyu Shan, Aldina Barral, Viviane Boaventura, Thomas T. Murooka, Abdel Soussi-Gounni, Camila I. de Oliveira, Jude E. Uzonna
Abstract
mice. Collectively, our results show that PTX3 contributes to the pathogenesis of CL by negatively regulating Th17 and IL-17A responses.
Topics & Concepts
PTX3PathogenesisInflammationInterleukin 17ImmunologyCutaneous leishmaniasisBiologyImmunityT cellTranscription factorImmune systemLeishmaniasisGeneGeneticsBiomarkers in Disease MechanismsResearch on Leishmaniasis Studies