Emodin-induced hepatotoxicity is enhanced by 3-methylcholanthrene through activating aryl hydrocarbon receptor and inducing CYP1A1 in vitro and in vivo
Meixi Wang, Zuqi Zhang, Panpan Ruan, Guangchen Zhang, Chengrong Xiao, Yuguang Wang, Yue Gao
Topics & Concepts
EmodinAryl hydrocarbon receptorPharmacologyOxidative stressChemistryMetaboliteIn vivoToxicityBiochemistryBiologyTranscription factorBiotechnologyGeneOrganic chemistryPhytochemistry and biological activity of medicinal plantsDrug-Induced Hepatotoxicity and ProtectionNatural Compound Pharmacology Studies