TDRD7 participates in lens development and spermiogenesis by mediating autophagosome maturation
Chaofeng Tu, Haiyu Li, Xuyang Liu, Ying Wang, Wei Li, Lanlan Meng, Weili Wang, Yong Li, Dongyan Li, Juan Du, Guangxiu Lu, Ge Lin, Yue‐Qiu Tan
Abstract
: CB: chromatoid bodies; CC: congenital cataract; CTSD: cathepsin D; DMSO: dimethyl sulfoxide; LAMP1: lysosomal-associated membrane protein 1; LECs: lens epithelial cells; MAP1LC3/LC3/Atg8: microtubule-associated protein 1 light chain 3; MEFs: mouse embryonic fibroblasts; NOA: non-obstructive azoospermia; OFZ: organelle-free zone; RG: RNA granules; SQSTM1/p62: sequestosome 1; TBC1D20: TBC1 domain family member 20; TDRD7: tudor domain containing 7; TEM: transmission electron microscopy; WT: wild type.
Topics & Concepts
BiologyAutophagyCell biologyLens (geology)SpermiogenesisAutophagosomeGeneticsApoptosisNucleusPaleontologyAutophagy in Disease and TherapyNatural Compounds in Disease Treatment