Prediction of non-muscle invasive bladder cancer recurrence using machine learning of quantitative nuclear features
Naoto Tokuyama, Akira Saito, Ryu Muraoka, Shuya Matsubara, Takeshi Hashimoto, Naoya Satake, Jun Matsubayashi, Toshitaka Nagao, Aashiq H. Mirza, Hans-Peter Graf, Eric Cosatto, Chin‐Lee Wu, Masahiko Kuroda, Yoshio Ohno
Abstract
Non-muscle invasive bladder cancer (NMIBC) generally has a good prognosis; however, recurrence after transurethral resection (TUR), the standard primary treatment, is a major problem. Clinical management after TUR has been based on risk classification using clinicopathological factors, but these classifications are not complete. In this study, we attempted to predict early recurrence of NMIBC based on machine learning of quantitative morphological features. In general, structural, cellular, and nuclear atypia are evaluated to determine cancer atypia. However, since it is difficult to accurately quantify structural atypia from TUR specimens, in this study, we used only nuclear atypia and analyzed it using feature extraction followed by classification using Support Vector Machine and Random Forest machine learning algorithms. For the analysis, 125 patients diagnosed with NMIBC were used; data from 95 patients were randomly selected for the training set, and data from 30 patients were randomly selected for the test set. The results showed that the support vector machine-based model predicted recurrence within 2 years after TUR with a probability of 90% and the random forest-based model with probability of 86.7%. In the future, the system can be used to objectively predict NMIBC recurrence after TUR.