Activation of the AKT/GSK-3β/β-catenin pathway via photobiomodulation therapy promotes neural stem cell proliferation in neonatal rat models of hypoxic-ischemic brain damage
Zhaoying Liao, Xuanzi Zhou, Siyu Li, Wei Jiang, Tingsong Li, Nanqing Wang, Nong Xiao
Abstract
Background: Hypoxic-ischemic brain damage (HIBD) significantly affects neurodevelopment in infants and is a leading cause of severe neurological morbidity and mortality in neonates. Our previous study found that photobiomodulation therapy (PBMT) improves the impaired spatial learning and memory of HIBD rat models. However, the neuroprotective mechanism conferred by PBMT in HIBD is unclear. Methods: . Results: . Conclusions: PBMT improved the spatial learning and memory of HIBD rats and promoted hippocampal NSC proliferation through the AKT/GSK-3β/β-catenin pathway.
Topics & Concepts
GSK-3Neural stem cellPI3K/AKT/mTOR pathwayProtein kinase BWnt signaling pathwayCyclin D1GSK3BBrain damageGlycogen synthaseChemistryCancer researchCell biologyStem cellKinaseBiologySignal transductionPhosphorylationCell cycleNeuroscienceBiochemistryCellConnexins and lens biologyPhotoreceptor and optogenetics researchLaser Applications in Dentistry and Medicine