Litcius/Paper detail

Tetrahydroquinoline: An Efficient Scaffold As mTOR Inhibitor for the Treatment of Lung Cancer

Udit Chaube, Rajdeep Dey, Suman Shaw, Bhumika Patel, Hardik Bhatt

2022Future Medicinal Chemistry22 citationsDOI

Abstract

Efforts have been made to find an efficient scaffold (and its substitution) that can be used for the treatment of lung cancer via mTOR inhibition. A detailed literature search was carried out for previously reported mTOR inhibitors. The present review is focused on lung cancer; therefore, descriptions of some mTOR inhibitors that are currently in clinical trials for the treatment of lung cancer are provided. Based on previous research findings, tetrahydroquinoline was found to be the most efficient scaffold to be explored for the treatment of lung cancer. A possible efficient substitution of the tetrahydroquinoline scaffold could also be beneficial for the treatment of lung cancer.

Topics & Concepts

Lung cancerScaffoldDiscovery and development of mTOR inhibitorsPI3K/AKT/mTOR pathwayCancerCancer researchLungMedicineClinical trialTreatment of lung cancerChemistryOncologyInternal medicineBiomedical engineeringSignal transductionBiochemistryPI3K/AKT/mTOR signaling in cancerSynthesis and Biological ActivityChemical Synthesis and Analysis
Tetrahydroquinoline: An Efficient Scaffold As mTOR Inhibitor for the Treatment of Lung Cancer | Litcius