The microtubule-associated histone methyltransferase SET8, facilitated by transcription factor LSF, methylates α-tubulin
Hang Gyeong Chin, Pierre‐Olivier Estève, Cristian Ruse, Jiyoung Lee, Scott E. Schaus, Sriharsa Pradhan, Ulla Hansen
Abstract
In addition, we found that the ability of LSF to facilitate this methylation is countered by factor quinolinone inhibitor 1 (FQI1), a specific small-molecule inhibitor of LSF. These findings suggest the general model that microtubule-associated proteins, including transcription factors, recruit or stimulate protein-modifying enzymes to target tubulins. Moreover, our results point to dual functions for SET8 and LSF not only in chromatin regulation but also in cytoskeletal modification.
Topics & Concepts
MicrotubuleTubulinCell biologyHistone methyltransferaseBiologyTranscription factorHistoneMethyltransferaseMitosisHistone methylationMethylationBiochemistryDNA methylationGene expressionDNAGeneEpigenetics and DNA MethylationCancer-related gene regulationGenomics and Chromatin Dynamics