Palladium‐Catalyzed Selective C‐F Bond Cleavage of Trifluoropropanamides Leading to (<i>Z</i>)‐<i>N</i>‐α‐Fluorovinylindoles
Xin Du, Weiming Zhang, Xing‐Guo Zhang, Hai‐Yong Tu
Abstract
Abstract A defluorinative heteroarylation of trifluoropropanamides through N ‐chelation‐assisted palladium‐catalyzed selective C−F activation has been developed. This reaction is compatible with a variety of trifluoropropanamides and indoles under mild reaction conditions to provide the stereospecific ( Z )‐ N ‐α‐fluorovinylindoles in moderate to good yields. magnified image
Topics & Concepts
ChemistryPalladiumStereospecificityCatalysisCleavage (geology)ChelationBond cleavageMedicinal chemistryStereochemistryOrganic chemistryEngineeringGeotechnical engineeringFracture (geology)Fluorine in Organic ChemistryCyclopropane Reaction MechanismsCatalytic C–H Functionalization Methods