Biocompatible and photocrosslinkable poly(ethylene glycol)/keratin biocomposite hydrogels
Chenshu Wang, Lijuan Wang, Xiuzhen Wan, Xuefeng Jiang, Jiang Yuan
Abstract
A biocompatible hydrogel is ideal for tissue engineering and regeneration. In this study, methacrylated keratin (KerMA) was synthesized for the first time and then blended with poly(ethylene glycol dimethacrylate) (PEGDMA) to form hydrogel through photocrosslinking. The chemical structure, gelation time, swelling behavior, hydrophilicity, cytotoxicity, and 3D printability of PEGDMA/KerMA hydrogels were characterized and exploited. The PEGDMA/KerMA hydrogels performed good cytocompatibility, providing potential applications for tissue engineering and regenerative medicine.
Topics & Concepts
Self-healing hydrogelsEthylene glycolBiocompositeMaterials scienceBiocompatible materialTissue engineeringSwellingPolymer chemistryChemical engineeringChemistryBiomedical engineeringComposite materialOrganic chemistryComposite numberMedicineEngineeringDyeing and Modifying Textile FibersSilk-based biomaterials and applicationsSkin Protection and Aging