Evolution of mammalian longevity: age-related increase in autophagy in bats compared to other mammals
Joanna Kacprzyk, Andrea G. Locatelli, Graham M. Hughes, Zixia Huang, Michael J. Clarke, Vera Gorbunova, Carlotta Sacchi, Gavin Stewart, Emma C. Teeling
Abstract
, mouse), that also showed an increase with age in both bat species. Further phylogenomic selection pressure analyses across eutherian mammals (n=70 taxa; 274 genes) uncovered 10 autophagy-associated genes under selective pressure in bat lineages. These molecular adaptations potentially mediate the exceptional age-related increase of autophagy signalling in bats, which may contribute to their longer healthspans.
Topics & Concepts
AutophagyBiologyLongevityTranscriptomeZoologyPopulationEvolutionary biologySenescenceGeneCell biologyGeneticsGene expressionApoptosisSociologyDemographyAutophagy in Disease and TherapyBat Biology and Ecology StudiesAdipose Tissue and Metabolism