Design, synthesis and biological evaluation of macrocyclic derivatives as TRK inhibitors
Pei Li, Shi Cai, Tong Zhao, Lin Xu, Dezhong Guan, Jinruo Li, Jinpei Zhou, Huibin Zhang
Topics & Concepts
Trk receptorTropomyosin receptor kinase AChemistryKinaseTropomyosin receptor kinase CTropomyosin receptor kinase BReceptor tyrosine kinaseTyrosine kinaseChinese hamster ovary cellCell cultureStereochemistryBiochemistryNeurotrophinReceptorPlatelet-derived growth factor receptorBiologyGeneticsNeurotrophic factorsGrowth factorQuinazolinone synthesis and applicationsMelanoma and MAPK PathwaysCytokine Signaling Pathways and Interactions