Diastereomeric Resolution Yields Highly Potent Inhibitor of SARS-CoV-2 Main Protease
Mark S. Cooper, Linlin Zhang, Mohamed Ibrahim, Kaixuan Zhang, Xinyuanyuan Sun, Judith Röske, Matthias Göhl, Mark Brönstrup, Justin K. Cowell, Lucie Sauerhering, Stephan Becker, Laura Vangeel, Dirk Jochmans, Johan Neyts, Katharina Rox, Graham P. Marsh, Hannah J. Maple, Rolf Hilgenfeld
Abstract
) is a promising candidate for further development as an antiviral treatment for COVID-19.
Topics & Concepts
DiastereomerChemistryStereochemistryProteaseProtease inhibitor (pharmacology)PolyproteinsEnzyme inhibitorEnzymeIC50Combinatorial chemistryIn vitroBiochemistryVirologyVirusViral loadBiologyAntiretroviral therapySARS-CoV-2 and COVID-19 ResearchComputational Drug Discovery MethodsRNA and protein synthesis mechanisms