New quinazolin-2,4-dione derivatives incorporating acylthiourea, pyrazole and/or oxazole moieties as antibacterial agents <i>via</i> DNA gyrase inhibition
Amal O. A. Ibrahim, Abdelfattah Hassan, Ahmed Mohamed Mosallam, A. Khodairy, Huda R. M. Rashdan, Aboubakr H. Abdelmonsef
Abstract
and -Cl enhance the antibacterial activity. Next, a molecular docking study between the synthesized derivatives and the target enzyme, DNA gyrase enzyme (PDB: 2xct) was undertaken to investigate intermolecular interactions between the compounds and target enzyme.
Topics & Concepts
OxazolePyrazoleDNA gyraseChemistryCombinatorial chemistryStereochemistryBiochemistryGeneEscherichia coliQuinazolinone synthesis and applicationsSynthesis and Characterization of Heterocyclic CompoundsCancer therapeutics and mechanisms