Burkholderia ubonensis High-Level Tetracycline Resistance Is Due to Efflux Pump Synergy Involving a Novel TetA(64) Resistance Determinant
Nawarat Somprasong, Carina M. Hall, Jessica R. Webb, Jason W. Sahl, David M. Wagner, Paul Keim, Bart J. Currie, Herbert P. Schweizer
Abstract
species contain a resident multicomponent efflux pump that allows them to respond to tetracyclines up to a certain concentration, the acquisition of the single-component TetA(64) by some species likely provides the synergy that these bacteria need to defend against high tetracycline concentrations in niche environments.
Topics & Concepts
EffluxMicrobiologyBurkholderia cepacia complexBurkholderiaAntibioticsTetracyclineBurkholderia pseudomalleiBiologyBacteriaAntibiotic resistanceGeneticsBurkholderia infections and melioidosis