MSC-mediated mitochondrial transfer restores mitochondrial DNA and function in neural progenitor cells of Leber’s hereditary optic neuropathy
Rui Wang, Feixiang Bao, Manjiao Lu, Xiaoyun Jia, Jiahui Xiao, Yi Wu, Qingjiong Zhang, Xingguo Liu
Topics & Concepts
Mitochondrial DNAReprogrammingInduced pluripotent stem cellHeteroplasmyMitochondrionMitochondrial diseaseBiologyLeber's hereditary optic neuropathyCell biologyProgenitor cellStem cellGeneticsCellGeneEmbryonic stem cellMitochondrial Function and PathologyATP Synthase and ATPases ResearchPluripotent Stem Cells Research