Evolving use and clinical outcomes of coronary intravascular lithotripsy: insights from an international, multicentre registry
Martijn J. H. van Oort, Ibtihal Al Amri, Brian O. Bingen, Federico Oliveri, Bimmer E. Claessen, Aukelien C. Dimitriu‐Leen, Tessel Vossenberg, Joëlle Kefer, Hany Girgis, Frank van der Kley, J. Wouter Jukema, José M. Montero Cabezas
Abstract
BACKGROUND: Intravascular lithotripsy (IVL) is increasingly used for treatment of coronary artery calcification. This study aimed to evaluate contemporary utilisation patterns, safety and efficacy of IVL in an unselected real-world patient cohort. METHODS: We included 454 patients undergoing IVL from May 2019 to February 2024 across seven centres in two European countries. Key endpoints included device success, technical success, procedural success, IVL-related complications and major adverse cardiovascular events (MACE) at 1-year follow-up. RESULTS: The cohort (mean age 73±9 years, 75% male) had a mean SYNTAX Score of 22.0±13.6. Device, technical and procedural success were achieved in 98%, 91% and 89% of patients, respectively. IVL-related complications occurred in six patients (1%). At 1-year follow-up, MACE was observed in 37 patients (13%). Over time, IVL use increased in patients with acute coronary syndrome (p=0.004) and in combination with intracoronary imaging (p=0.002), while use of other calcium modification devices decreased (p=0.034). CONCLUSION: In this real-world registry, IVL demonstrated efficacy across diverse clinical and anatomical settings. High success rates, low complication rates and MACE rates were observed acutely and at 1-year follow-up. Utilisation patterns evolved over time, with increased adoption in acute scenarios and alongside intracoronary imaging.