Controllable stereoinversion in DNA-catalyzed olefin cyclopropanation <i>via</i> cofactor modification
Jingya Hao, Wenhui Miao, Sheng‐Mei Lu, Yu Cheng, Guoqing Jia, Can Li
Abstract
a synergetic effect with DNA residues at the active site. These findings underline the important role of cofactor modification in DNA catalysis and thus pave the way for the rational engineering of DNA-based biocatalysts.
Topics & Concepts
CyclopropanationCofactorChemistryOlefin fiberCatalysisStereochemistryDNACombinatorial chemistryEnzymeBiochemistryCyclopropane Reaction Mechanisms